s
- SaaS
- Software as a Service
- Safe Mode
- Samba
- Sample
- Sample Rate
- Sampling
- SAN
- Storage Area Network
- Sandbox
- Sass
- Syntactically Awesome Style Sheets
- SATA
- Serial Advanced Technology Attachment
- Scalable
- Scanner
- Scareware
- Schema
- Scraping
- Screen Burn
- Screen Tearing
- Screenshot
- Script
- Scroll Bar
- Scroll Wheel
- Scrolling
- SCSI
- Small Computer System Interface
- SD
- Secure Digital
- SDK
- Software Development Kit
- SDLC
- System Development Lifecycle
- SDRAM
- Synchronous Dynamic Random Access Memory
- SDS
- Software-Defined Storage
- SDSL
- Symmetric Digital Subscriber Line
- Search Engine
- Secondary Memory
- Secondary Storage
- Sector
- Seed
- Semaphore
- Serial Number